Antimalarial Activity of Seed Extracts of Schinus molle Against Plasmodium berghei in Mice

Background. Malaria is a major public health problem in developing countries. In Ethiopian, the seeds of Schinus molle are used for management malaria. Therefore, current study aimed to evaluate vivo antimalarial activity hydro-alcoholic crude extract and solvent fractions Plasmodium berghei infected mice. Methods. An 80 percent methanolic were tested at 100, 200 400 mg/kg doses. The parasitemia level, packed cell volume, body weight, survival date rectal temperature anti-malarial extracts. One-way ANOVA followed by post hoc Tukey’s HSD multiple comparison test was employed result expressed mean ± SEM (standard error mean). Results. curative highest dose aqueous fraction 69.86% 73.82% ( p < 0.001), respectively. prophylactic test, had 72.39% 0.001) suppression activity. Among fractions, only chloroform significantly attenuated volume reduction. mice treated with longer than vehicle-treated 0.001). Conclusion. experiment finding showed that significant prophylaxis anti-plasmodial This revealed has promising against berghei. However, further confirmatory studies, isolation characterization active constituents recommended.